李立

擅长： 医学影像诊断和分子影像学研究

简介： 现任中山大学附属肿瘤医院影像与微创介入中心教授/主任医师，博士生导师。华南肿瘤学国家重点实验室(2004DA105074)课题组负责人。广东省高等学校“千百十工程”第七批省级培养对象。 专业学会兼职： 中国生物物理学会分子影像学专业委员会第一届委员 中国抗癌协会大肠癌专业委员会肝转移学组第一届委员 广东省抗癌协会大肠癌专业委员会常务委员 广东省放射学会心胸学组委员 临床医疗与科学研究经验： 李立教授长期从事医学影像诊断和分子影像学研究工作，在智能磁共振造影剂研制、新型纳米探针研发、肿瘤分子分期、多模态分子成像理论与动物模型研究取得了重要成果。发表通讯作者/第一作者SCI收录论著24篇，其中，通讯作者(或共同通讯作者)论著发表在Scientific Reports, Biomaterials, Clinical Cancer Research, Nanoscale, Cancer, Contrast Media & Molecular Imaging等国际著名期刊。以第一发明人获得新型钆纳米造影剂、乳腺影像CAD系统、稳定表达Tet-off Advanced鼻咽癌细胞模型发明专利3项，申报多模态分子成像探针发明专利1项。 科研基金： 1、国家自然科学基金面上项目，81271622、钆-纳米金双模态分子成像探针及其成像相互影响机制的研究、2013/01-2016/12、85万元、主持。 2、国家自然科学基金面上项目，81071207、鼻咽癌生物发光与磁共振多模态成像模型研究、2011/01-2013/12、35万元、主持。 3、广州市科技支撑计划项目，2010J-E151、东方女性适用的乳腺钼靶摄影计算机辅助诊断系统、2011/01-2013/12、15万元、主持。 4、高校基本科研业务费中山大学重大项目培育和新兴交叉学科资助计划项目、10ykjcll、肿瘤分子影像基础研究、2010/07-2012/12、30万元、主持。 5、国家自然科学基金面上项目，30770629、含钆纳米材料磁共振分子影像造影剂的研制、2008/01-2010/12、28万元、主持。 6、广州市科技计划项目，2006Z3-D2041、新型磁共振造影剂—钆掺杂复合纳米材料的研制、2006/01-2008/12、30万元、主持。 近年来发表论著(*通讯作者)： 1. Cao CY, Shen YY, Wang JD, Li L*, Liang GL*. Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents. Sci Rep 2013,3,1024 doi:10.1038/srep01024 (2013). 2. Tian XM, Shao YZ, He HQ, Liu H, Shen YY, Huang WL*, Li L*. Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging. Nanoscale 2013, 5(8), 3322-3329 3. Shen Y, Shao Y, He H, Tan Y, Tian X, Xie F*, Li L*. Gadolinium(3+)-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo. Int J Nanomedicine 2013,8:119-127 4. Cai HM, Cui CY, Tian HY, Zhang M, Li L*. A novel approach to segment and classify regional lymph nodes on computed tomography images. Comput Math Method M 2012,2012:145926 doi:10.1155/2012/ 145926 5. Shao YZ, Tian XM, Hu WY, Zhang YY, Liu H, He HQ, Shen YY, Xie FK, Li L*. The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI. Biomaterials 2012,33(27):6438-6446 6. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Efficiency of ferritin as an MRI reporter gene in NPC cells is enhanced by iron supplementation. J Biomed Biotechnol 2012,2012:434878 doi:10.1155/2012/434878 7. Pang YC#, Li L#, Hu WY, Peng YX, Liu LZ, Shao YZ*. Computerized segmentation and characterization of breast lesions in dynamic contrast-enhanced MR images using Fuzzy c-means clustering and snake algorithm. Comput Math Method M 2012,2012:634907 doi:10.1155/2012/634907 (2011 SCI IF 0.684) 8. Cui CY, Cai HM, Liu LZ, Li LR, Tian HY, Li L*. Quantitative analysis and prediction of regional lymph node Status in rectal cancer based on computed tomography imaging. Eur Radiol 2011,21(11):2318-2325 9. Shao YZ, Liu LZ, Song XQ, Cao RH, Liu H, Cui CY, Li X, Bie MJ, Li L*. A novel one-step synthesis of Gd3+ incorporated mesoporous SiO2 nanoparticles for use as an efficient MRI contrast agent. Contrast Media Mol Imaging 2011,6(2):110-118 10. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Development and applications of a nasopharyngeal carcinoma Tet-Off cell line. Oncol Lett 2011, 3(2):525-530 11. Shao YZ, Liu LZ, MJ, Li CC, Wu YP, Xie XM, Li L*. Characterizing the clustered microcalcifications on mammograms to predict the pathological classification and grading: a mathematical modeling approach. J Digital Imaging 2011, 24(5):764-771 12. Liu LZ, Liang SB, Li L*, Mao YP, Tang LL, Tian L, Liao XB, Cui CY, Lin AH, Ma J*. Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer 2009,115(9):1995-2003 13. Cui CY, Liu LZ, Ma J, Liang SB, Tian L, Tang LL, Li L*. Trigeminal nerve palsy in nasopharyngeal carcinoma: Correlation between clinical findings and magnetic resonance imaging. Head Neck 2009,31(6):822-828 14. Li L, Liu LZ, Wu QL, Mo YX, Liu XW, Cui CY, Wan DS*. CT-guided core needle in diagnosis of pancreatic diseases with an automated biopsy gun. J Vasc Interv Radiol 2008,19(1):89-94 15. Ma J, Liu L, Tang L, Zong J, Lin A, Lu T, Cui N, Cui C, Li L*. Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: prognostic value and staging categories. Clin Cancer Res 2007,13(5):1445-1452 16. Liu LZ, Zhang GY, Xie CM, Liu XW, Cui CY, Li L*. Magnetic resonance imaging of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: patterns of spread. Int J Radiat Oncol Biol Phys 2006,66(3):721-730 17. Li L, Wu PH, Huang JL, Liu RY, Zeng YX, Huang WL*. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Int J Cancer 2006,118(8):2064-2071